先天性巨结肠症(Hirschsprung’sdisease,HD)是因神经节细胞不能在肠壁内聚集、定位和分化等因素导致肠壁内神经节细胞缺如。对两因素以及两因素之间在形成HD共同作用的研究未见报道。本文利用免疫组织化学的方法,同时观察HD病例中RET蛋白、NCAM在无神经节(aganglion,AG)肠段和 Hirschsprung’s disease (HD) is the absence of ganglion cells in the intestinal wall caused by the inability of ganglion cells to accumulate, locate and differentiate in the intestinal wall. No studies have been reported on two factors and their interaction in forming HD. In this paper, the use of immunohistochemical methods, simultaneous observation of RET cases RET protein, NCAM in the absence of ganglion (aganglion, AG) intestine and