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AIM To study the clinical peculiarities of patients infected with different genotypes of hepatitis C virus (HCV).METHODS Genotypes of HCV in 90 HCV-RNA-positive patients in Xuzhou area were examined. Clinical data of the patients were compared.RESULTS HCV Ⅱamounted to 78.9% (71/ 90), predominating over HCV Ⅲand HCV Ⅱ/ Ⅲwhich held 18.9% (17/ 90) and 2.2% (2/ 90) respectively in the area. ALT level and ALT positivity rate were higher in HCV Ⅱthan in HCV Ⅲ(P＜0.05) within a range of ＞200 U/ L. Anti-HCV OD value and anti-HCV positivity rate when its OD value was over 2, were lower in HCV Ⅱthan in HCV Ⅲ(P＜0.05). Most jaundice patients (87%) were infected with HCV Ⅱ. No significant difference was found in age, sex and transfusion experience between HCV Ⅱand HCV Ⅲpatients (P＞0.05).CONCLUSION Distribution of HCV genotypes in Xuzhou area is consistent with that in the whole China, reflecting its distribution in eastern coastal areas. The immunogenicity of HCV Ⅱis lower than that of HCV Ⅲ, but the damage of hepatic function is more serious in HCV Ⅱpatients than in HCV Ⅲpatients, which might be due to different pathogenic mechanisms. Infection with HCV Ⅱ/ Ⅲis related to repeated usage of blood products and repeated hemodialysis. HCV Ⅱand HCV Ⅲ, we believe, might play coordinated roles in pathogenesis.