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用肿瘤坏死因子α(TNF -α)干预培养的MG 63细胞(人成骨肉瘤来源)。结果显示:TNF -α上调MG 63细胞核蛋白p65表达,下调护骨素(OPG)mRNA和蛋白质表达。吡咯二硫氨基甲酸酯不能阻止TNF -α下调MG 63细胞OPG的作用。
Cultured MG 63 cells (human osteogenic sarcoma source) were intervened with tumor necrosis factor alpha (TNF-alpha). The results showed that TNF-α up-regulated the expression of nuclear protein p65 of MG 63 cells and down-regulated the mRNA and protein expression of osteoprotegerin (OPG). Pyrrolodithiocarbamate did not prevent TNF-α from down-regulating the OPG of MG63 cells.