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用疏水星形聚合物模拟疏水性药物,研究其与两亲聚合物的自组装,探讨两亲性聚合物包载疏水性药物的机理.用开环聚合合成了5种两亲聚己内酯-聚乙二醇两嵌段共聚物(PCL-b-PEG)和4种疏水星型聚己内酯(star-branched polycaprolactone,SPCL),使用相分离法使PCL-b-PEG与SPCL进行自组装.浊度、SEM、动态光散射(dynamic light scattering,DLS)和FTIR结果表明,PCL-b-PEG与SPCL能够进行自组装,而且PCL-b-PEG中PEG长度和PCL含量对自组装有影响;PCL-b-PEG/SPCL形成的自组装体的粒径与SPCL的臂长、臂数和加入量有关.
Hydrophobic star polymer was used to simulate the hydrophobic drug, and its self-assembly with amphiphilic polymer was studied to explore the mechanism of amphiphilic polymer encapsulating hydrophobic drug.A series of amphiphilic polycaprolactone - PCD-b-PEG and four star-branched polycaprolactone (SPCL) were used to make PCL-b-PEG and SPCL from The results of turbidity, SEM, dynamic light scattering (DLS) and FTIR indicate that PCL-b-PEG and SPCL can be self-assembled and the PEG length and PCL content in PCL-b- The size of self-assembly of PCL-b-PEG / SPCL was related to the arm length, arm number and amount of SPCL.