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目的：开发慢性动物实验的理想麻醉剂。方法：以传统麻醉剂戊巴比妥钠为对照，应用静松灵氯胺酮合剂对32只豚鼠进行听脑干反应(auditory brainstem response，ABR)测试。结果与结论：与戊巴比妥钠相比，氯胺酮静松灵合剂具有起效迅速、ABR测试完毕后苏醒快、死亡率低等优点。所测得的ABR诸参数与应用戊巴比妥钠一致。“,”Aim: To look for a satisfying anesthetic for chronic animal experiment. Methods:Experimental group and controlgroup were anesthetized by jingsongling-ketamine mixture and pentobartitone respectively and all the guinea pigs were tested of au-ditory brainstem response (ABR). Festlts and Conclusion: The results revealed that jingsongling-ketamine mixture workedfaster, and had a shorter awaking duration after the test and a lower death rate than pentobartitone did while ABR testing resultswere consistent between the 2 groups.