目的探究s-100p蛋白和ki-67在胃肠道上皮癌中的表达及临床意义。方法选取医院2014年1月-2016年1月收治的30例胃肠道上皮癌患者作为研究组,另选同期30例健康体检者作为对照组,采用免疫组织化学法检测2组受试者s-100p蛋白和ki-67表达水平并进行比对。结果研究组患者s-100p蛋白和ki-67表达水平高于对照组,差异均有统计学意义(P<0.05)。胃肠道上皮癌患者组内不同病理分级患者相比较,s-100p蛋白和ki-67表达水平差异具有统计学意义(P<0.05)。结论 s-100p蛋白和ki-67表达水平可作为胃肠道上皮癌预后的参照指标,值得在临床中推广使用。 Objective To investigate the expression and clinical significance of s-100p protein and ki-67 in gastrointestinal epithelial carcinoma. Methods Thirty patients with gastrointestinal cancer who were admitted from January 2014 to January 2016 in our hospital were selected as the study group and 30 healthy subjects were selected as the control group. Immunohistochemistry -100p protein and ki-67 expression levels and compared. Results The expression levels of s-100p and ki-67 in study group were significantly higher than those in control group (P <0.05). The expression of s-100p protein and ki-67 in patients with different histological grades of gastrointestinal cancer were significantly different (P <0.05). Conclusion The expression of s-100p protein and ki-67 may serve as a reference index for the prognosis of gastrointestinal epithelial carcinoma and is worth popularizing in clinic.