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作者报道4例(男3例,女1例,年龄6～8岁)先天性肾上腺增生(congenital adrenal hyperplasia,CAH)的真性性早熟患儿用黄体生成素释放激素类似物(luteinizing hormone-releasing hormone analog,LHRHa)治疗的经过。患儿的CAH、21羟化酶缺乏症确诊于3～6岁,都接受了标准剂量的氢化可的松和氟氢可的松治疗。2年内患儿CAH得到有效控制,但患儿阴毛继续增多,生长率仍高于正常,骨龄仍提前,男孩出现睾丸增大,女孩乳腺发育,血清性激素高于同龄儿童,基础的和
The authors report that 4 patients (3 males, 1 females, aged 6 to 8 years) with congenital adrenal hyperplasia (CAH) in patients with precocious puberty with luteinizing hormone-releasing hormone analogue (luteinizing hormone-releasing hormone analog, LHRHa) after treatment. Children with CAH, 21 hydroxylase deficiency diagnosed in 3 to 6 years old, have received the standard dose of hydrocortisone and fludrocortisone treatment. 2 years of children with effective control of CAH, but the incidence of pubic hair in children continued to increase, the growth rate is still higher than normal, the bone age is still ahead of the boys increased testis, the girls breast development, serum sex hormones than children of the same age, basic and