Parkinson病(PD)的特点是黑质区域多巴胺神经元进行性丧失。目前对导致这种现象的原因尚不完全清楚,氧化机制说、自由基说等理论均存有争议。作者推测PD病人脑脊液(CSF)中可能存在影响多巴胺类神经元功能及生长的因素,为证实之而作如下研究。 Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra region. At present, the reasons for this phenomenon are not fully understood. The theory of oxidation, the theory of free radicals, and other theories are all controversial. The authors hypothesize that there may be factors affecting the function and growth of dopaminergic neurons in cerebrospinal fluid (CSF) of patients with PD, as evidenced by the following studies.