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多相脂质体139能够明显抑制癌细胞 DNA 合成,其抑制~3H—TdR 掺入艾氏腹水癌细咆 DNA 合成的曲线为缓慢递增型,表现为可逆性抑制并具有浓度依赖性。药物剂量为1.0mg/ml 时对 RNA 合成呈现轻度抑制并导致癌细胞核酸含量减少。“139”对S—180鼠肿瘤细胞蛋白质合成作用显著,最高抑制率为67.8%。对 RRL 蛋白质合成抑制率为46.8%,这种抑制作用是在延迟了十分钟后表现出来的,说明反应体系中聚核糖核蛋白体上已经开始合成肽链的核糖核蛋白体仍可继续完成肽链的合成,而新的核糖核蛋白体重新由其亚基组合时则受到一定抑制。“139”对肽酰—~3H—嘌吟霉素结合反应并无抑制作用,故不是转肽抑制剂.
Multiphase liposome 139 can significantly inhibit the DNA synthesis of cancer cells. The inhibition of DNA synthesis by ~ 3H-TdR incorporation into Ehrlich ascites cells is slowly increasing, showing reversible inhibition and concentration-dependent. A dose of 1.0 mg / ml showed mild inhibition of RNA synthesis and resulted in a decrease in cancer cell nucleic acid content. “139” had a significant effect on the protein synthesis of S-180 mouse tumor cells with the highest inhibition rate of 67.8%. The inhibition rate of RRL protein synthesis was 46.8%. This inhibition was demonstrated after a delay of ten minutes, indicating that the ribonucleoprotein body on the ribonucleoprotein body that has started to synthesize the peptide chain in the reaction system can still continue to complete the peptide Chain synthesis, while the new ribonucleoprotein body by the combination of its subunits was a certain inhibition. “139” has no inhibitory effect on the peptidyl- ~ 3H-purinomycin binding reaction and therefore is not a transabdominal peptide inhibitor.