[Objectives] To analyze the clinical treatment effect on oromaxillo-facial multi-space infection. [Methods] Based on the clinical data about 72 oromaxillo-facial multi-space infection cases from January 2016 to December 2016,the double-blind study was used to divide them into study group(36 cases) and control group(36 cases). As for the control group,36 patients with oromaxillo-facial multi-space infections were given the conventional treatment; as for the study group,36 patients were given the treatment of abscess incision and drainage combined with hyperbaric oxygen based on conventional treatment. The total effective rate and complication rate were compared between the two groups. [Results]The total effective rate and complication rate under the study group were higher than under the control group,and the difference was statistically significant( P < 0. 05). [Conclusions] The clinical treatment effect on oromaxillo-facial multi-space infection was very significant,and the treatment was worthy of promotion and application in clinical practice. [Objectives] To analyze the clinical treatment effect on oromaxillo-facial multi-space infection cases. [Methods] Based on the clinical data about 72 oromaxillo-facial multi-space infection cases from January 2016 to December 2016, the double-blind study was used as for the control group, 36 patients with oromaxillo-facial multi-space infections were given the conventional treatment; as for the study group, 36 patients were given the treatment of abscess incision and drainage combined with hyperbaric oxygen based on conventional treatment. The total effective rate and complication rate were more between the two groups. [Results] The total effective rate and complication rate under the study group were higher than under the control group, and the difference was statistically significant (P <0.05). [Conclusions] The clinical treatment effect on oromaxillo-facial multi-space infection was very significant, and the treatment was worthy of promotion and application in clinical practice.