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药物的起效取决于药物的吸收与分布,作用的中止则取决于药物的清除。药物消除的方式主要靠体内生化转化。药物生化转化主要靠酶的促进,主要场所是肝脏微粒体,不少药物经过生物转化变为活性或毒性代谢物,因此不能简单地把药物在体内的生物转化叫做解毒作用,若二药或更多的药并用后,肝毒性相加,可导致肝中毒、肝坏死,严重者可造成死亡。处方1 异烟肼 0.1×100 0.1 tid po VB_6 10mg×100 20mg tid po 鲁米那 0.03×12 0.09 qd po HS 剖析异烟肼大部分在肝内代谢,形成乙酰化异烟肼,对肝有毒性,引起肝细胞受损,出现转氨酶升高、黄疸,严重者出现肝小叶坏死。然鲁米那又为药酶诱导剂,可加速异烟肼生物转化为对肝有
The onset of the drug depends on the absorption and distribution of the drug, and the termination of the action depends on the drug’s clearance. The main way to eliminate drugs rely on the body biochemical transformation. Drug biochemical conversion mainly by the promotion of enzymes, the main site is the liver microsomes, many drugs after biotransformation into active or toxic metabolites, it can not simply be the drug in vivo biotransformation called detoxification, if two drugs or more After the combination of multiple drugs, the liver toxicity, can lead to liver poisoning, liver necrosis, severe cases can cause death. Formulation 1 Isoniazid 0.1 × 100 0.1 tid po VB_6 10 mg × 100 20 mg tid po Lumina 0.03 × 12 0.09 qd po HS Profile Isoniazid metabolism mostly in the liver to form acetylated isoniazid and is toxic to the liver , Causing damage to liver cells, increased transaminases, jaundice, severe cases of hepatic lobule necrosis. However, Rumi that medicine drug inducer, can accelerate the biological conversion of isoniazid to the liver