论文部分内容阅读
目的探讨载脂蛋白Ee4等位基因(APOE e4)与外伤性颅内血肿体积的关系。方法利用聚合酶链式反应—限制性片段长度多态性方法(PCR-RFLP)检测163例脑外伤患者的APOE基因型,分析其中117例颅内血肿患者的等位基因频率分布;比较APOE e4携带者组和非携带者组的颅内血肿体积的差别,结果117例颅内血肿患者有20例(17%)为APOE e4携带者,97例(83%)为非APOE e4携带者。APOE e4在各组之间不存在明显差别(P=0.927,0.955)。APOE e4携带组患者颅内血肿体积[(44.6±7.35)mL]与非携带组[(22.6±1.03)mL]之间存在显著性差异(P= 0.000)。结论携带APOE e4的患者其颅内血肿的体积明显大于非携带APOE e4者,提示APOE e4对颅内血肿体积的增大有促进作用,进而在一定程度上影响颅脑损伤患者的预后。
Objective To investigate the relationship between apolipoprotein Ee4 allele (APOE e4) and traumatic intracranial hematoma volume. Methods The genotypes of APOE in 163 traumatic brain injury patients were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The allele frequency distribution in 117 patients with intracranial hematoma was analyzed. Compared with APOE e4 The difference in intracranial hematoma volume between carriers and non-carriers showed that 20 (17%) of 117 patients with intracranial hematomas were APOE e4 carriers and 97 (83%) were non-APOE e4 carriers. APOE e4 did not differ significantly among the groups (P = 0.927, 0.955). There was a significant difference (P = 0.000) between intracranial hematoma volume [(44.6 ± 7.35) mL] and [22.6 ± 1.03 mL] in APOE e4-carrying group. Conclusions The volume of intracranial hematoma in patients with APOE e4 is significantly larger than those without APOE e4, suggesting that APOE e4 may promote the increase of intracranial hematoma volume, and thus affect the prognosis of patients with craniocerebral injury to a certain extent.