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Toll样受体(Toll-like receptor, TLR)是一类重要的模式识别受体,其胞外结构域可识别特定的病原相关分子模式(Pathogen-associated molecular patterns, PAMPs),胞内的TIR (Toll-like/IL-1 receptor)结构域则参与启动胞内信号转导,诱导细胞产生活性氧中间体(Reactive oxygen intermediate)、活性氮中间体(Reactive nitrogen intermedi-ate)和促炎症因子,在感染早期发