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目的研究新型β-环糊精的降脂效果。方法 24只大鼠高脂血症模型建立后,每组6只随机分为空白组、高脂模型组(灌胃1%CMC-Na水溶液)、新药组(新型β-环糊精降脂)和考来烯胺组(CLST降脂)。分别于给药前和给药后的2周和4周取鼠血测总胆固醇(TC)和三酰甘油(TG)。结果 (1)新药组小鼠给药前后体重、毛色、饮食、饮水及精神状态无变化;(2)空白组和高脂模型组内TG比较差异无统计学意义(t=1.195,t=1.095,均P>0.05),TC水平比较差异也无统计学意义(t=0.285,t=0.104,均P>0.05)。(3)新药组给药后2周大鼠TG和TC水平明显降低,TG和TC分别与给药前比较差异有统计学意义(t=3.912,t=17.801,均P<0.05)。(4)新药组给药后2周和4周TG相比差异没有统计学意义(t=0.369,P>0.05),而TC水平差异有统计学意义(t=3.56,P<0.05)。(5)考来烯胺组给药后2周和4周比较,TG和TC差异无统计学意义(t=0.002,t=0.381,P>0.05)。结论新型β-环糊精是一种无不良反应的降脂药物,且对总胆固醇的调节作用存在时间依赖性。
Objective To study the lipid-lowering effect of novel β-cyclodextrin. Methods After establishment of model of hyperlipemia in 24 rats, 6 mice in each group were randomly divided into blank group, high fat model group (intragastric administration of 1% CMC-Na aqueous solution), new drug group (new β-cyclodextrin lipid- And cholestyramine group (CLST lipid-lowering). Blood samples were taken for total cholesterol (TC) and triglyceride (TG) before administration and 2 weeks and 4 weeks after administration. Results (1) There was no significant difference in body weight, coat color, diet, drinking water and mental state before and after administration in the new drug group. (2) There was no significant difference in TG between the blank group and the high fat model group (t = 1.195, t = 1.095 , All P> 0.05), there was no significant difference in TC level (t = 0.285, t = 0.104, all P> 0.05). (3) The levels of TG and TC in the new drug group were significantly decreased 2 weeks after administration, TG and TC were significantly different (t = 3.912, t = 17.801, both P <0.05). (4) There was no significant difference in TG between two weeks and four weeks after administration (t = 0.369, P> 0.05), but there was a significant difference in TC levels between the two groups (t = 3.56, P <0.05). (5) There was no significant difference of TG and TC between test group and control group (t = 0.002, t = 0.381, P> 0.05) 2 weeks and 4 weeks after administration. Conclusion The new β-cyclodextrin is a lipid-lowering drug with no adverse reactions, and the regulation of total cholesterol has a time-dependent manner.