近年来,研究发现体内一氧化氮(NO)主要由NO合成酶(nitric oxide synthase,NOS)合成。NO作为生物体内一种重要的信息分子和效应分子~([1]),具有自由基的化学性质和多种生物功能,能调节细胞信息的传递、防御、损害以及哺乳动物的生殖过程~([2-4])。然而,精液中异常的NO浓度对男性生育的影响机制未见诸报道。本课题深入研究了精 In recent years, it has been found that nitric oxide (NO) in the body is mainly synthesized by nitric oxide synthase (NOS). NO, as an important information molecule and effector molecule in organism, has the chemical properties of free radicals and various biological functions and regulates the transmission of cell information, defense, damage and mammalian reproductive processes. [2-4]). However, the mechanism of the effect of abnormal NO concentration in sperm on male fertility has not been reported. This topic in-depth study of the essence