Antisense相关论文
Antiviral effect of antisense oligodeoxynucleotides complementary to hepatitis B virus X gene in vit
Objective To investigate the antiviral effect of antisense phosphorothioate oligodeoxynucleotides （ASODNs） complementary t......
Co-transfection of MRP and bcl-2 antisense S-oligodeoxynucleotides reduces drug resistance in cispla
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目的 探讨脂质体转染Survivin反义寡核苷酸(ASODN)对体外培养的增生期血管瘤内皮细胞增殖、凋亡的影响.方法 人工合成Survivin ASO......
目的 观察反义表皮生长因子受体(EGFR)对人肺腺癌细胞系放射敏感性的影响.方法 在脂质体介导下用质粒pcDNA3-反义EGFR(pcDNA3-anti......
目的 建立豚鼠形觉剥夺性近视动物模型,玻璃体腔内注射不同浓度的N-甲基-D-天冬氨酸受体1(NMDAR1)反义寡核苷酸(ASON),观察NMDAR1 ......
目的 研究黏着斑激酶(focal adhesion kinase,FAK)在人增生性瘢痕发病机制中的作用.方法 体外分离、培养人增生性瘢痕成纤维细胞(h......
目的 优化制备包裹反义寡核苷酸(ASODN)的α-氰基丙烯酸正丁酯(BCA)纳米粒,观察其C6脑胶质瘤细胞的生长抑制作用.方法 以BCA为载体......
目的为探讨抑制人端粒酶的模板RNA成分(hTR)能否抑制人胰腺癌细胞的端粒酶活性及细胞生长能力.方法用分子克隆方法将593 bp 的hTR......
目的 验证下调miR-93表达对人脑胶质瘤细胞株的生长和侵袭抑制作用.方法 合成miR-93抑制物,应用脂质体转染人脑胶质瘤细胞以抑制其......
目的 探讨核因子κB(NF-κB)p65反义寡核苷酸(ASOND)对大鼠肝星状细胞(HSC)增殖和I型胶原表达的影响.方法 Ⅳ型胶原酶消化密度梯度......
Objective:To study the effects of antisense PTEN gene on the growth and invasion of glioma cells. Methods:A pcDNA3. 1/Hy......
研究表明许多人类肿瘤内都有显著的缺氧区域.处于缺氧状态的肿瘤细胞仍能不断增殖、浸润,许多基因表达的改变依赖于缺氧诱导因子-1......
目的探讨bcl-2 反义硫代磷酸寡脱氧核苷酸(antisense phosphorothioate oligodeoxynucleotide,AS-PS-ODN)诱导细胞凋亡的调控机理.......
Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achie......
A major portion of the mammalian genome is transcribed to produce large numbers of noncoding RNAs(ncRNAs).During the pas......
目的研究胞嘧啶(C)含量对反义探针肿瘤特异性聚集的影响，为最佳反义显像碱基序列的筛选提供帮助。方法以survivin为靶序列制备3种(A......
A full-length cDNA of dehydrin BcDh2 from Boea crassifolia and its antisense nucleotidesequence have been transferred in......
目的 探讨miRNA-34a反义寡核苷酸对非小细胞肺癌细胞的影响及分子机制.方法 qRT-PCR检测人非小细胞肺癌细胞株HCC827和人正常肺细......
目的 探讨基质金属蛋白酶-9反义寡核苷酸(MMP-9ASODN)对肺腺癌A549细胞增殖与凋亡的影响,并初步探讨其机制.方法 MTT法检测MMP-9AS......
Suppressing Effects of Down-regulating DNMT1 and DNMT3b Expression on the Growth of Human Cholangioc
Hypermethylation in the promoter region is an important epigenetic mechanism for the transcriptional repression of a num......
目的 评价脂质体介导对99Tcm-表皮生长因子受体(EGFR) mRNA反义PNA体外靶细胞摄取、荷瘤裸鼠体内特异显像及生物学分布的影响.方法......
目的 探讨99Tcm标记的小鼠双微体扩增基因2(MDM2) mRNA的ASON和错义寡核苷酸(ASONM)对前列腺癌细胞株LNCaP目的基因表达的影响,为......
目的 探讨99Tcm标记针对小鼠双微体扩增基因(MDM2) mRNA的ASON(MDM2反义探针)用于前列腺癌无创性基因显像的价值.方法 以HYNIC为螯......
目的 探讨反义寡核昔酸多位点封闭HBx基因对人类肝癌组织在裸小鼠皮下移植瘤发生的影响.方法 50只裸小鼠随机等分为5组,1组为对照......
为研究应用锁核酸(locked nucleic acid,LNA)抗HBV的作用,我们设计针对HBV S基因的反义寡核苷酸,分别经过LNA、硫代反义寡核苷酸(p......
Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primar
Objective: To explore the effect of homeobox B2 (HOXB2) antisense oligodeoxynucleotides (asodn) on the proliferation a......
Construction of antisense Bmi-1 expression plasmid and its inhibitory effect on K562 cells prolifera
Background Bmi-1 gene determines the proliferative capacity of normal and leukemia stem cells. Expression of Bmi-1 has b......
Background No efficient therapy for liver fibrosis has been available. This study was aimed to provide evidence that the......
Apoptosis of drug-resistant human ovarian carcinoma cell line COC1/DDP induced by survivin antisense
Currently, surgery-oriented treatment plays a major role in the treatment of ovarian cancer patients. But 5-year surviv......
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OBJECTIVE To investigate the therapeutic potential of amphiregulin antisense RNA delivered by adenoviral vector in a hum......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 探讨生存素(Survivin)反义寡核苷酸(ASODN)诱导人胃癌细胞SGC7901凋亡的作用.方法 设计合成特异性靶向Survivin的ASODN,将胃......
Objective: To investigate the effect of antisense, human telomerase reverse transcriptase (hTERT) mRNA oligodeoxynucleot......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Summary: Silencing ATM gene gave rise to enhanced apoptotic response to irradiation and irradiation-like chemotherapy ag......
Objective: The aim of our study was to investigate the biological effects of Bcl-XL antisense oligodeoxynucleotide (ASOD......
目的探讨脂质体-硫代磷酸化修饰的C-erbB2反义脱氧寡核苷酸(C-erbB2 antisense phosphorothioated oligodeoxynucleotides, C-erbB......
A full-length cDNA of dehydrin BcDh2 from Boea crassifolia and its antisense nucleotide sequence have been transferred i......
Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primar
Objective: To explore the effect of homeobox B2 (HOXB2) antisense oligodeoxynucleotides (asodn) on the proliferation an......
