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目的:探究硫酸镁联合小剂量阿司匹林对子痫前期患者氧化性低密度脂蛋白,内脂素水平及临床疗效的影响。方法:选取2015年1月到2016年7月我院收治的子痫先期患者90例,根据随机数字对照表分为对照组与试验组,各45例。对照组患者给予静脉滴注硫酸镁治疗,试验组联合给予小剂量阿司匹林治疗。比较两组患者临床疗效、氧化性低密度脂蛋白及内脂素水平。结果:治疗结束后,与对照组相比,试验组临床总有效率较高(P<0.05),治疗后两组氧化性低密度脂蛋白及内脂素水平较治疗前降低(P<0.05);与对照组相比,试验组氧化性低密度脂蛋白及内脂素水平较低(P<0.05)。结论:硫酸镁联合小剂量阿司匹林对子痫先期患者有明显治疗效果,推测其可能与氧化性低密度脂蛋白及内脂素水平降低有关。
Objective: To investigate the effects of magnesium sulfate combined with low-dose aspirin on oxidative low density lipoprotein, visfatin and clinical efficacy in patients with preeclampsia. Methods: 90 patients with preeclampsia admitted to our hospital from January 2015 to July 2016 were selected and divided into control group and experimental group according to random number table (45 cases). Control group patients given intravenous infusion of magnesium sulfate, the experimental group were given low-dose aspirin. The clinical efficacy, oxidized low density lipoprotein and visfatin levels were compared between the two groups. Results: Compared with the control group, the total clinical effective rate of the experimental group was significantly higher after the treatment (P <0.05), and the levels of oxidized low density lipoprotein and visfatin decreased after treatment (P <0.05) Compared with the control group, the levels of oxidized low density lipoprotein and visfatin in the experimental group were lower (P <0.05). Conclusion: Magnesium sulfate combined with low-dose aspirin has obvious therapeutic effect on the patients with preeclampsia, suggesting that it may be related to the decrease of oxidized low density lipoprotein and visfatin.