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目的:分析正常眼压性青光眼患者外周血中白细胞介素-6(IL-6)、白细胞介素-12(IL-12)与白内障对照组测量值上有无差异,从而探讨免疫因素在正常眼压性青光眼发病机制中的意义。方法:正常眼压性青光眼患者37例,白内障对照组40例。两组年龄、性别无显著性差异。分别抽取外周血3mL,采取双抗体夹心酶联免疫吸附法(ABC-ELISA)方法分别测量IL-6,IL-12含量。结果:正常眼压性青光眼组IL-6,IL-12含量分别为(1.402±2.297)pg/mL和(12.475±3.973)pg/mL;白内障对照组含量分别为(8.214±5.355)pg/mL和(20.116±4.216)pg/mL。两组差异均有统计学意义(P<0.05)。结论:正常眼压性青光眼患者外周血中IL-6,IL-12含量低于白内障对照组,提示免疫因素可能在正常眼压性青光眼发病机制中起着重要的作用。
Objective: To analyze whether there is any difference in the measured values of IL-6, IL-12 and cataract in the peripheral blood of patients with normal tension glaucoma, Significance of Ocular Pressure Glaucoma in Pathogenesis. Methods: 37 cases of normal pressure glaucoma patients, 40 cases of cataract control group. There was no significant difference between the two groups in age and sex. Peripheral blood was drawn 3mL respectively, and the contents of IL-6 and IL-12 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ABC-ELISA). Results: The levels of IL-6 and IL-12 in normal tension glaucoma group were (1.402 ± 2.297) pg / mL and (12.475 ± 3.973) pg / mL, respectively. The contents of cataract in control group were (8.214 ± 5.355) pg / mL And (20.116 ± 4.216) pg / mL. The differences between the two groups were statistically significant (P <0.05). Conclusion: The content of IL-6 and IL-12 in peripheral blood of patients with normal tension glaucoma is lower than that of cataract control group, suggesting that immune factors may play an important role in the pathogenesis of normal tension glaucoma.