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为了探讨尿纤维连接蛋白（Ｆｉｂｒｏｎｅｃｔｉｎ，Ｆｎ）对早期糖尿病肾病的诊断意义，本文采用酶联免疫吸附（ＥＬＩＳＡ）法测定了２５例早期糖尿病肾病患者尿Ｆｎ含量。结果表明早期糖尿病肾病患者尿Ｆｎ含量明显高于正常对照组（Ｐ＜０．０１），尿．Ｆｎ含量与尿白蛋白含量呈显著正相关（Ｐ＜０．０１）。随着肾病的加重，尿Ｆｎ含量亦显著增加（Ｐ＜０．０５），以尿Ｆｎ浓度６０．１μｇ／ｍＬ作为判断有无早期糖尿病肾病的截断值，其敏感性为８８％，特异性为９０％，本研究表明尿Ｆｎ测定可作为诊断早期糖尿病肾病的一个敏感指标。
In order to investigate the significance of fibronectin (Fn) in the diagnosis of early diabetic nephropathy, urine Fn levels were measured in 25 patients with early diabetic nephropathy by enzyme-linked immunosorbent assay (ELISA). The results showed that early diabetic nephropathy urinary Fn content was significantly higher than the normal control group (P <0.01), urine. Fn content and urinary albumin content was significantly correlated (P <0.01). With the aggravation of nephropathy, urinary Fn content also increased significantly (P <0.05). Urinary Fn concentration of 60.1 μg / mL was used as a cut-off to determine the presence or absence of early diabetic nephropathy with a sensitivity of 88% and a specificity of 90%, this study shows that urinary Fn assay can be used as a sensitive indicator of early diagnosis of diabetic nephropathy.