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目的 为了了解内皮型一氧化氮合成酶 (eNOS)基因G894T突变位点与中国人群缺血性脑卒中之间的关系。方法 我们利用PCR和分子杂交技术对北京地区 2 94例缺血性脑卒中患者及 2 80例非卒中对照的eNOS基因G894T突变位点进行了检测和分析。结果 G894T位点在两组人群中的分布均符合Hardy -Weinberg遗传平衡定律 ,但该位点基因型频率及等位基因频率在两组人群中分布无差异。结论 eNOS基因G894T突变不是中国人群缺血性脑卒中发病的遗传学危险因素。
Objective To understand the relationship between the G894T mutation of endothelial nitric oxide synthase (eNOS) gene and ischemic stroke in Chinese population. METHODS: PCR and molecular hybridization were used to detect and analyze the G894T mutation site of 2 94 ischemic stroke patients and 280 non-stroke controls in Beijing. Results The distribution of G894T locus was in accordance with Hardy-Weinberg’s law of genetic balance in both groups, but there was no difference in genotype frequency and allele frequency between the two groups. Conclusion The eNOS gene G894T mutation is not a genetic risk factor for ischemic stroke in Chinese population.