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在5个参加研究的中心(Freetown、Karachi、Bombay、Madras和Chetput)共有307例瘤型和界线瘤型麻风病人被随机安排接受下列三种治疗方法之一:1)DDS100mg/日;2)DDS100mg/日加利福平600mg/日;3)利福平600mg/日加Isoprodian(每片含PTH175mg、异烟肼175mg和DDS50mg) 2片/日。对于体重不足60kg或超过80kg的病人,剂量稍有变动。排除活动性结核、其它消耗性疾病和精神病。曾连续或不连续地用过3年以上DDS者也不包括在内。病人的主要特点见表1。治疗前及3年的治疗中定期做身体检查、基本的实验室检查(BUN、GOT、GPT和Hb)、皮肤抹片和
A total of 307 patients with tumor and borderline anemia in five participating centers (Freetown, Karachi, Bombay, Madras and Chetput) were randomized to receive one of the following three treatment options: 1) DDS 100 mg / day; 2) DDS 100 mg / Day Ciprofloxacin 600mg / day; 3) Rifampicin 600mg / Day plus Isoprodian (each containing PTH175mg, Isoniazid 175mg and DDS50mg) 2 tablets / day. For patients weighing less than 60kg or more than 80kg, the dose varies slightly. Exclusion of active tuberculosis, other wasting disease and mental illness. Those who have used DDS continuously or discontinuously for more than 3 years are not included. The main characteristics of patients in Table 1. Before and 3 years of treatment, regular physical examinations, basic laboratory tests (BUN, GOT, GPT and Hb), skin smear and