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一、概述自1944年Halbrecht首先报道新生儿溶血病(简称ABOHDN)以来,该病逐渐成为新生儿高间接胆红素血症的一个主要原因,约占17.5%和22%。上海1978年报道,在712例ABOHDN中新生儿死亡1.4%,重度黄疸27.2%,重度贫血4.8%,核黄疸5.9%,且约50%发生于第1胎。严重影响着优生优育。二、发病机理多见于母血型为O,子为A或B型者。理论上母血型为A或B型,若与婴儿血型不合(婴儿为B、AB或A、AB)也应使婴儿
I. Overview Since Halbrecht first reported neonatal hemolytic disease (ABOHDN) in 1944, the disease has gradually become a major cause of neonatal indirect hyperbilirubinemia, accounting for 17.5% and 22%. Shanghai reported in 1978 that in 712 ABOHDNs neonatal deaths were 1.4%, severe jaundice was 27.2%, severe anemia was 4.8%, and nuclear jaundice was 5.9%, with about 50% occurring in the first child. Seriously affect the prenatal and postnatal care. Second, the pathogenesis more common in maternal blood type O, sub-A or B type. Theoretically maternal blood type A or B type, if the blood type does not match with the baby (the baby is B, AB or A, AB) should also make the baby