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四因素两剂量按正交表Ｌ８（２７）设计用家兔和小鼠在密闭舱内进行８组试验。γ射线的两剂量，对家兔为０．０３７５和０．００７５Ｇｙ／ｄ，对小鼠为０．０４７３和０．００９５Ｇｙ／ｄ，苯、甲苯和一氧化碳两浓度分别为１８２±３３和４０±１５ｍｇ／ｍ３、４０７±６８和９０±３０ｍｇ／ｍ３、２７８±８和９３±４ｍｇ／ｍ３。实验每天２ｈ，每周５ｄ，持续８周。结果如下：（１）γ射线、苯和甲苯对诱发家兔淋巴细胞染色体畸变、微核、ＳＣＥ以及家兔和小鼠骨髓细胞染色体畸变都有明显影响，但未发现一氧化碳对诱发家兔和小鼠细胞遗传学效应有明显的作用。（２）γ射线和苯诱发家兔血液淋巴细胞双＋环、总畸变细胞、微核和微核细胞以及诱发小鼠骨髓细胞单体畸变和总畸变细胞，γ射线和甲苯诱发淋巴细胞畸变细胞以及小鼠骨髓细胞无着丝粒，苯和甲苯诱发淋巴细胞无着丝粒、总畸变、畸变细胞和总畸变细胞以及诱发小鼠骨髓细胞总畸变细胞等，都呈现明显的交互作用。（３）８组试验的复合细胞遗传效应中，各指标均以四因素皆为高剂量组合的①号组试验最高。但即使是四因素皆为低剂量组合的⑧号组试验，各指标亦均高于对照组，且除姐妹染色单体互换（ＳｉｓｔｅｒＣｈｒｏｍａｔｉｄＥｘｃｈａｎｇ?
Four factors and two doses were designed in orthogonal table L8 (27). Eight groups of rabbits and mice were designed in an airtight chamber. The two doses of gamma-rays were 0.0375 and 0.0075 Gy / day for rabbits, 0.0473 and 0.0095 Gy / week for mice, respectively, with concentrations of benzene, toluene and carbon monoxide of 182 ± 33 and 40 ± 15 mg, respectively / M3, 407 ± 68 and 90 ± 30 mg / m3, 278 ± 8 and 93 ± 4 mg / m3. The experiment was conducted daily for 2 hours and 5 days a week for 8 weeks. The results are as follows: (1) γ-ray, benzene and toluene have significant effects on chromosome aberration, micronucleus, SCE and chromosomal aberrations in rabbit and mouse bone marrow cells induced by lymphocytes in rabbits, but no effect of carbon monoxide on rabbits and small Mouse cytogenetic effect has a significant effect. (2) γ-ray and benzene-induced double-loop, total aberration, micronuclei and micronuclei in rabbit blood lymphocytes and mononuclear and total aberrant cells in mouse bone marrow cells induced by γ-rays and toluene, As well as murine bone marrow cells without centromeres, benzene and toluene-induced lymphocyte-free centromere, total aberrations, aberrant cells and total aberration cells, as well as the total bone marrow cells induced aberrant cells in mice, showed a significant interaction. (3) Among the eight groups, the composite cytogenetic effect in each group was highest in all the four groups. But even the four factors were low dose combination ⑧ group test, the indicators were also higher than the control group, and in addition to sister chromatid exchange (SisterChromatidExchang?