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目的探讨幽门螺杆菌(Hp)感染对冠心病患者血清指标的影响,为其预防与治疗提供依据。方法选择2012年1月-2014年12月100例经冠状动脉造影确诊的冠心病患者为研究对象,另选择100例健康体检者为对照组,检测血清中Hp Ig G、高敏C-反应蛋白(hs-CRP)、白介素6(IL-6)、同型半胱氨酸(Hcy)、甘油三酯(TG)和总胆固醇(TC)等指标。结果冠心病患者组血清Hp Ig G的阳性率高于对照组,差异有统计学意义(P<0.05);冠心病患者组TG、TC、hs-CRP、IL-6和Hcy水平较对照组高,高密度脂蛋白(HDL)较对照组低,差异有统计学意义(P<0.05)。血清Hp Ig G阳性患者TG、TC、低密度脂蛋白(LDL)、hs-CRP、IL-6和Hcy水平高于Hp Ig G检测阴性患者,差异有统计学意义(P<0.05)。结论 Hp感染与冠心病的发生有相关性,Hp感染通过引起炎性反应、影响同型半胱氨酸和脂类代谢异常,促进动脉粥样硬化的发生和发展。
Objective To investigate the influence of Helicobacter pylori (Hp) infection on serum indexes in patients with coronary heart disease (CHD) and provide basis for its prevention and treatment. Methods From January 2012 to December 2014, 100 patients with coronary heart disease diagnosed by coronary angiography were selected as study objects. Another 100 healthy subjects were selected as the control group, and serum Hp Ig G, high-sensitivity C-reactive protein hs-CRP, IL-6, Hcy, triglyceride and total cholesterol. Results The positive rate of Hp Ig G in CHD patients was higher than that in control group (P <0.05). The levels of TG, TC, hs-CRP, IL-6 and Hcy in CHD patients were higher than those in control subjects , High-density lipoprotein (HDL) than the control group, the difference was statistically significant (P <0.05). The levels of TG, TC, LDL, hs-CRP, IL-6 and Hcy in serum Hp Ig G positive patients were higher than those in negative Hp Ig G patients (P <0.05). Conclusion Hp infection is associated with the development of coronary heart disease. Hp infection can promote the occurrence and development of atherosclerosis by causing inflammatory reaction, affecting homocysteine and lipid metabolism abnormalities.