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本文采用放射免疫法和比色法测定 6 8例 HIE及 30例正常新生儿血浆NO、NOS及血清 PRL 活性水平 ,探讨一氧化氮 (NO)、一氧化氮合成酶 (NOS)及催乳素 (PRL)在新生儿缺氧缺血性脑病 (HIE)的病机、病情进展、预后中的作用及临床意义。结果显示 :HIE急性期 NO、NOS、PRL水平较正常新生儿明显升高 (P<0 .0 5 ) ,中度和重度 HIE三项指标升高更显著 (P均 <0 .0 1 ) ,且 HIE惊厥组急性期血清PRL 水平显著高于非惊厥组 (P<0 .0 1 ) ,且与惊厥发作持续时间呈正相关 (r=0 .485 ,P<0 .0 1 )。提示 :NO、NOS、PRL水平高低与 HIE患儿脑损伤严重程度有关 ,可作为判断病情、预后及惊厥是否发作的指标
In this paper, radioimmunoassay and colorimetry were used to detect plasma NO, NOS and serum PRL activity in 68 HIE patients and 30 normal neonates. The levels of nitric oxide (NO), nitric oxide synthase (NOS) and prolactin PRL in neonatal hypoxic-ischemic encephalopathy (HIE) pathogenesis, progression and prognosis in the role and clinical significance. The results showed that the levels of NO, NOS and PRL in acute HIE were significantly higher than those in normal neonates (P <0.05), and those in moderate and severe HIE were more significant (all P <0.01) The level of PRL in acute phase of HIE seizure group was significantly higher than that in non-seizure group (P <0.01), and positively correlated with the seizure duration (r = 0.485, P <0.01). It is suggested that the levels of NO, NOS and PRL are related to the severity of brain injury in children with HIE and may be used as indicators to judge whether the condition, prognosis and seizure are seizure or not