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本文作者观察了感染细粒棘球蚴的沙鼠用阿苯达唑进行长疗程治疗后,蚴囊的生发层是否对药物产生抗性。自沙鼠腹腔接种4000只羊源的细粒棘球蚴原头节。6个月后,将20只沙鼠随机分为两组,一组用阿苯达唑50mg/kg.天治疗3个月,另一组为对照。治疗毕,剖杀动物,取包囊称重,然后将上述两组包囊再分别随机分为两组,一组在含50μg/L阿苯达唑亚砜的培养液中培养14d,另一组为对照。随机选取上述四组包囊,分别植入正常沙鼠腹腔中,
The authors observed whether the germinal layer of the lacteal sac was resistant to drugs after a long course of treatment with albendazole in gerbils infected with Echinococcus granulosus. Abdominal inoculation of gerbils from 4000 sheep origin of Echinococcus granulosus original head. Six months later, twenty gerbils were randomly divided into two groups: one group treated with albendazole 50 mg / kg for 3 months and the other as control. After treatment, the animals were sacrificed and the cysts were weighed. The two groups of cysts were then randomly divided into two groups. One group was cultured for 14 days in a medium containing 50 μg / L albendazole sulfoxide, another Group as a control. Randomly selected the above four groups of cysts were implanted in normal abdominal cavity of gerbils,