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目的 提高不能切除的晚期胰腺癌的化疗效果。方法 晚期不能切除的胰腺癌 76例 ,随机分为两组 ,其中 5 2例在剖腹探查、胆肠或胃肠转流的同时经胃十二指肠动脉或脾动脉插入化疗泵 ,术后经泵用 5 - Fu和丝裂霉素进行区域性化疗 ,即区域治疗组 ;2 4例在行胆肠或胃肠转流术后 ,用 5 - Fu和丝裂霉素进行系统性全身化疗 ,即全身对照组。结果 区域治疗组疼痛缓解率为 73.1% ,肿瘤缩小率为 36 .5 % ,胰头癌中位生存期为 10 .8个月 ,胰体尾癌为 7.8个月 ,均比对照组的相应结果41.7%、16 .7%、7.6个月、4.8个月高 (P<0 .0 1)。结论 经动脉区域性化疗治疗晚期胰腺癌的效果优于系统性全身化疗。
Objective To improve the chemotherapy effect of unresectable advanced pancreatic cancer. Methods A total of 76 patients with unresectable pancreatic cancer were randomly divided into two groups. Among them, 52 patients underwent laparotomy, cholecystolithiasis or gastrointestinal diversion and chemotherapy through the gastroduodenal artery or splenic artery. After operation, The pump was treated with 5 - Fu and mitomycin for regional chemotherapy, that is, the regional treatment group. Twenty - four patients underwent cholecystolithiasis or gastrointestinal bypass after systemic systemic chemotherapy with 5 - Fu and mitomycin, The whole body control group. Results The regional pain relief rate was 73.1% in the treatment group, the tumor shrinkage rate was 36.5%, the median survival time in pancreatic cancer was 10.8 months, and the duration of pancreatic body and tail cancer was 7.8 months, which were all higher than those in the control group 41.7%, 16.7%, 7.6 months and 4.8 months (P <0.01). Conclusion Regional arterial chemotherapy for advanced pancreatic cancer is better than systemic systemic chemotherapy.