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引起腹腔内感染的主要致病菌为厌氧的松脆杆菌及需氧的肠杆菌。有人分别证实灭滴灵对前者,妥布霉素对后者及兼性厌氧菌引起的腹腔内感染有效。1980年1月至1981年4月,作者在温哥华总医院将两种药物合用,并配合相应外科手术治疗腹腔内感染,获得较好效果。诊断依据为临床表现结合手术发现、体温升高及血白细胞增多等。用药方法系灭滴灵500mg、妥布霉素1.6mg/kg静脉滴注,每8小时一次。肾功能不良者,妥布霉素依其血内浓度适当减量。用药中除一般临床观察外,须注意血白细胞计数及肝、肾功能。病人年龄21～89岁,平均50岁,女25例,男23例,计49例次发作(1例男性发作2次)。21例为急性穿孔
The main pathogenic bacteria causing intraperitoneal infections are anaerobic pine bacillus and aerobic enterobacter. Some people have confirmed that metronidazole on the former, tobramycin on the latter and facultative anaerobic bacteria caused by intraperitoneal infection effective. January 1980 to April 1981, the author of the Vancouver General Hospital combined the two drugs, and with the corresponding surgical treatment of intraperitoneal infection, get better results. Diagnosis based on clinical manifestations combined with surgery found that the body temperature and blood leukocytosis and so on. Medication method is metronidazole 500mg, tobramycin 1.6mg / kg intravenously, once every 8 hours. Renal dysfunction, tobramycin according to their blood concentration appropriate reduction. In addition to the general clinical observation of drugs, we must pay attention to white blood cell count and liver and kidney function. Patients aged 21 to 89 years, mean 50 years old, 25 females, 23 males, 49 episodes (1 male episodes twice). 21 cases of acute perforation