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目的:探讨肿瘤标志物细胞角蛋白21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、鳞癌相关抗原(SCCAg)检测对肺癌诊断的临床应用价值。方法:采用电化学发光法检测60例肺癌患者(肺癌组)、60例肺部良性病变患者(良性对照组)和60例健康体检者(正常对照组)的四种肿瘤标志物,并用统计学方法比对分析。结果:肺癌患者组血清四种肿瘤标志物水平明显高于良性对照组和正常对照组(P<0.05)。结论:检测CYFRA21-1、NSE、CEA、SCCAg可有效提高肺癌诊断的敏感性,对肺癌的早期诊断有重要的临床应用价值。
Objective: To investigate the clinical application of tumor marker cytokeratin 21-1 (CYFRA21-1), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and squamous cell carcinoma associated antigen (SCCAg) in the diagnosis of lung cancer value. Methods: Four kinds of tumor markers were detected by electrochemiluminescence in 60 patients with lung cancer (lung cancer group), 60 patients with benign lung disease (benign control group) and 60 healthy controls (normal control group) Method comparison analysis. Results: The serum levels of four tumor markers in patients with lung cancer were significantly higher than those in benign control group and normal control group (P <0.05). Conclusion: The detection of CYFRA21-1, NSE, CEA and SCCAg can effectively improve the sensitivity of lung cancer diagnosis and has important clinical value in the early diagnosis of lung cancer.