论文部分内容阅读
一、IC的局部形成在研究血清病早期阶段,人们推测在小球中固定的免疫复合物,不管那一种,都是以同一机制(即CIC在局部沉积)形成的。但给实验动物注射预先制备的CIC,仅能在间质和内皮下沉积,而且即使注射血管活性胺,有时也不能使其沉积在上皮下。因此推测在有些情况下,抗原和抗体可以在小球内相互作用。这种在小球内不同部位进行的局部抗原-抗体反应及随之形成的颗粒型IC,已为很多试验系统所证实。大鼠自身IC肾病的发生,过去公认是含小管上皮刷状缘抗原的CIC形成并在小球
First, the local formation of IC In the early stages of the study of serum serogroups, it was speculated that immune complexes immobilized in the globules, in either case, are formed by the same mechanism (ie, localized deposition of CIC). However, injection of pre-prepared CIC into experimental animals can only be deposited under the stroma and the endothelium, and sometimes it is not allowed to deposit under the epithelium even when injected with vasoactive amines. Therefore, it is speculated that in some cases, the antigen and the antibody may interact within the globule. This local antigen-antibody reaction and the consequent formation of particulate ICs in different parts of the pellet have been demonstrated by many test systems. The occurrence of IC nephropathy in rats itself was previously recognized as a CIC with tubule epithelioid brush border antigen and formed in pellets