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目的 观察补充锌制剂、维生素C对染砷小鼠肝脏组织超氧化物岐化酶 (SOD)水平、丙二醛 (MDA )含量的影响 ,比较这两种物质针对砷染毒小鼠的抗氧化作用的强弱。方法 昆明种小鼠饮用含砷水同时通过灌胃给予不同种类的抗氧化剂 ,8周后 ,测定小鼠肝脏SOD活性及MDA含量。结果 干预 8周后 ,测定小鼠肝脏组织的SOD活性及MDA的含量 ,可见维生素C组的小鼠肝SOD活性上升、MDA含量下降达到正常对照组水平 (P <0 .0 5 ) ,锌制剂组仅小鼠肝SOD活性上升 ,达到正常对照组水平 (P <0 .0 5 )而MDA含量与染毒对照组差异无统计学意义 (P >0 .0 5 )。结论 提示补充一定剂量的锌制剂、维生素C对染砷小鼠的脂质过氧化有拮抗作用 ,维生素C对慢性砷中毒的防治效果要优于锌制剂。
Objective To observe the effects of zinc supplementation and vitamin C on the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver of arsenic-exposed mice and compare the anti-oxidation The strength of the role. Methods Kunming mice were challenged with arsenic-containing water and given different kinds of anti-oxidants by gavage. After 8 weeks, SOD activity and MDA content in liver of mice were determined. Results After intervention for 8 weeks, the activity of SOD and the content of MDA in liver of mice were measured. The activity of SOD in liver of vitamin C group increased and MDA content decreased to the level of normal control group (P <0.05) The activity of liver SOD increased only in the normal control group (P <0.05), but there was no significant difference between the control group and the MDA content (P> 0.05). Conclusions suggest that supplementation of a certain dose of zinc preparations, vitamin C on arsenic-induced lipid peroxidation antagonism, vitamin C on chronic arsenic poisoning control effect is better than zinc preparations.