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目的 :探讨可溶性选择素与脑梗死的关系。方法 :用ELISA方法测定 77例脑梗死和 2 8例正常人可溶性E ,P 和L 选择素 (sE ,sP 和sL 选择素 )血清水平 ,并分析它们与脑梗死部位、大小、神经功能缺损程度及合并症的关系。结果 :急性脑梗死患者sE 和sP 选择素血清水平明显高于正常人 ,大、小面积梗死组选择素水平均明显高于腔隙性梗死组 ,脑梗死合并感染者sL 选择素水平亦明显升高。不同脑梗死部位及不同神经功能缺损评分患者间各可溶性选择素水平无显著性差异。结论 :可溶性选择素与脑梗死临床变化有较密切关系 ,测定它们血清水平有助于脑梗死病情变化的监测
Objective: To investigate the relationship between soluble selectin and cerebral infarction. Methods: Serum levels of soluble E, P and L-selectin (sE, sP and sL-selectin) in 77 patients with cerebral infarction and 28 normal controls were measured by ELISA and their relationship with the infarction size, size, neurological deficit And the relationship between complications. Results: The serum levels of sE and sP-selectin in patients with acute cerebral infarction were significantly higher than those in normal subjects, and the levels of selectin in large and small infarct patients were significantly higher than those in patients with lacunar infarcts. The levels of sL-selectin in patients with cerebral infarction and infection were also significantly increased high. There was no significant difference in the levels of soluble selectin between different cerebral infarction sites and different neurological deficit scores. Conclusion: Soluble selectin is closely related to the clinical changes of cerebral infarction. Measuring their serum levels may be helpful to monitor the changes of cerebral infarction