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目的评价国产吉西他滨(GEM)联合顺铂(DDP)治疗晚期非小细胞肺癌的临床疗效及不良反应。方法39例晚期非小细胞肺癌患者应用吉西他滨联合顺铂化疗,吉西他滨1000mg/m2,静脉滴注30min,d1,8;DDP30mg/m2,静脉滴注,d2～4,21d为1周期,化疗2～3周期后评价疗效。结果39例患者中,1例CR,15例PR,17例SD,6例PD,总有效率(CR+PR)为41.0%。鳞癌有效率为38.5%;腺癌有效率为42.3%;Ⅲb期有效率为47.6%,Ⅳ期有效率为33.3%;主要毒副反应为骨髓抑制和胃肠道反应,其中白细胞下降至Ⅲ度者为15.4%,血小板下降至Ⅲ、Ⅳ度者为20.5%,Ⅲ度以上恶心呕吐的发生率为7.7%。结论国产吉西他滨联合顺铂治疗晚期非小细胞肺癌疗效较好,毒副反应较轻,患者耐受良好,值得临床推广。
Objective To evaluate the clinical efficacy and adverse reactions of gemcitabine combined with cisplatin (DDP) in the treatment of advanced non-small cell lung cancer. Methods 39 cases of advanced non-small cell lung cancer patients were treated with gemcitabine combined with cisplatin, gemcitabine 1000mg / m2, intravenous infusion 30min, d1,8; DDP30mg / m2 intravenous drip, d2 ~ 4,21d for 1 cycle, chemotherapy 2 ~ After 3 cycles evaluation of efficacy. Results Among 39 patients, CR was 1 CR, 15 PR, 17 SD and 6 PD. The total effective rate (CR + PR) was 41.0%. The effective rate of squamous cell carcinoma was 38.5%, that of adenocarcinoma was 42.3%, that of stage Ⅲb was 47.6%, and that of stage Ⅳ was 33.3%. The major toxicities were myelosuppression and gastrointestinal reaction, Degree was 15.4%, thrombocytopenia to Ⅲ, Ⅳ degree was 20.5%, Ⅲ degree above the incidence of nausea and vomiting was 7.7%. Conclusion The domestic gemcitabine combined with cisplatin in the treatment of advanced non-small cell lung cancer has better curative effect, less toxic and side effects, and the patients are well tolerated and worthy of clinical promotion.