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目的 :分析元胡止痛滴丸治疗原发性痛经的配伍合理性。方法:选取元胡止痛滴丸当中的主要代表成分作为研究对象,在网络药理学的基础上,分析元胡止痛滴丸治疗原发性痛经的作用机制以及配伍合理性。结果:所有化合物均可以作用于所形成的23个潜在蛋白靶点以及19条相关的通路当中。其中,作用通路主要包括血管舒张、中枢镇痛、炎症及免疫等多个环节,各个通路群间通过均有共同的靶点相连,且显示出了不同成分之间多靶点、多途径的协同效果。结论:元胡止痛滴丸主要作用于中枢镇痛等靶点蛋白发挥止痛、活血的功效,在原发性痛经的治疗中具有较好的配伍合理性。
Objective: To analyze the rationality of compatibility of Yuanhu Zhitong Dripping Pills in treating primary dysmenorrhea. Methods: The main constituents of Yuanhu Zhitong dropping pills were selected as research objects. Based on the network pharmacology, the mechanism and compatibility of Yuanhu Zhitong pills in treating primary dysmenorrhea were analyzed. Results: All compounds were able to act on the 23 potential protein targets formed and 19 related pathways. Among them, the pathways of action mainly include vasodilation, central analgesia, inflammation and immune and other links, each pathway group through a common target point are connected, and shows the different components of multi-target, multi-channel synergy effect. CONCLUSION: Yuanhu Zhitong Dripping Pill mainly acts on central analgesic and other target proteins to exert the effect of relieving pain and promoting blood circulation, and has good compatibility and rationality in the treatment of primary dysmenorrhea.