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目的:对短舌紫菀Aster sampsonii全草的化学成分进行研究。方法:以甲醇-石油醚-乙醚1∶1∶1提取,用氯仿进行萃取,对氯仿部位采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,NMR,HMBC等)进行结构鉴定,并对部分化合物进行生物活性实验。结果:分离鉴定了10个化合物,分别为(4αR,4′αR,5S,5′S,9αR,9′αR)-4,4′,4α,4′α,5,5′,6,6′,7,7′,8,8′-dodecahydro-3,3′,4α,4′α,5,5′-hexamethyl-2H,2′H-9α,9′α-binaphtho[2,3-b]furan-2,2′-dione(1),furanoligularenone(2),(4αR,5S,8αR)-4α,5,6,7,8,8α-hexahydro-8α-hydroxy-3,4α,5-trimethylnaphtho[2,3-b]furan-2(4H)-one(3),(4αR,5S,8αS)-4α,5,6,7,8,8α-hexahydro-8α-hydroxy-3,4α,5-trimethylnaphtho[2,3-b]furan-2(4H)-one(4),methyl 1′-hydroxy-2′,6′-dimethoxy-4′-oxocyclohexanacetate(5),1′-hydroxy-2′-methoxy-4′-oxocyclohexanacetate methyl(6),loliolide(7),jacaranone(8),β-谷甾醇(9),木栓酮(10),生物活性筛选结果表明化合物3对金黄色葡萄球菌有弱的抑制作用。结论:其中化合物1~8为首次从该属植物中分离得到。
Objective: To study the chemical constituents of Aster sampsonii whole plant. Methods: The extracts were extracted with 1: 1: 1 methanol-petroleum ether-ether and extracted with chloroform. The chloroform fractions were separated and purified by various column chromatographies and identified by spectral data analysis (MS, NMR, HMBC, etc.) Some compounds were tested for biological activity. Results: Ten compounds were isolated and identified as (4αR, 4’αR, 5S, 5’S, 9αR, 9’αR) -4,4 ’, 4α, 4’α, 5,5’, 6,6 ’, 7,7’, 8,8’-dodecahydro-3,3 ’, 4α, 4’α, 5,5’-hexamethyl- 2H, 2’H-9α, 9’α-binaphtho [2,3- furan-2-dione (1), furanoligularenone (2), (4αR, 5S, 8αR) -4α, 5,6,7,8,8α-hexahydro- -trimethylnaphtho [2,3-b] furan-2 (4H) -one (3), (4αR, 5S, 8αS) -4α, 5,6,7,8,8α-hexahydro-8α-hydroxy-3,4α , 5-trimethylnaphtho [2,3-b] furan-2 (4H) -one (4), methyl 1’-hydroxy-2 ’, 6’-dimethoxy-4’-oxocyclohexanacetate 2-methoxy-4’-oxocyclohexanacetate methyl (6), loliolide (7), jacaranone (8), β-sitosterol and thromboxane (10) Cocci has a weak inhibitory effect. Conclusion: Compounds 1 ~ 8 were isolated from this genus for the first time.