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目的:探讨硫普罗宁联合复方甘草甜素对中重度酒精性肝病的疗效。方法:将46例酒精性肝病患者随机分为两组,每组23例。治疗组采用硫普罗宁200mg和复方甘草甜素注射液40ml静脉滴注,对照组采用谷胱甘肽1.2g静脉滴注。治疗前后分别检测两组血清总胆红素(TBil)、丙氨酸氨基转移酶(ALT)和门冬氨酸氨基转移酶(AST),并对照两组疗效。结果:治疗后治疗组血清TBil、ALT和AST均值明显低于对照组(37.85±19.68 vs.68.33±13.07μmol·L~(-1),P<0.01;56.33±14.78 vs.89.38±35.67u·L~(-1),P<0.01:79.76±24.65 vs.121.32±23.44u·L~(-1),P<0.01)。治疗组的总有效率明显高于对照组(P<0.05)。结论:硫普罗宁联合复方甘草甜素可明显改善酒精性肝病患者肝功能,使总有效率明显提高。
Objective: To investigate the effect of tiopronin combined with compound glycyrrhizin on moderate and severe alcoholic liver disease. Methods: 46 cases of alcoholic liver disease were randomly divided into two groups, 23 cases in each group. The treatment group with tiopronin 200mg and compound glycyrrhizin injection 40ml intravenous infusion, the control group with glutathione 1.2g intravenous infusion. Serum total bilirubin (TBil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured before and after treatment, and the curative effect of the two groups were compared. Results: After treatment, mean serum TBil, ALT and AST in the treatment group were significantly lower than those in the control group (37.85 ± 19.68 vs.68.33 ± 13.07 μmol·L -1, P <0.01; 56.33 ± 14.78 vs.89.38 ± 35.67u · L -1, P <0.01: 79.76 ± 24.65 vs.121.32 ± 23.44u · L -1, P <0.01). The total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). Conclusion: The combination of tiopronin and compound glycyrrhizin can significantly improve the liver function of patients with alcoholic liver disease, so that the total effective rate was significantly increased.