Objective To explore the possible mechanism of rAd-p53 involved in glucose metabolism by observing the different effects of rAd-p53 on high-fat diet(HFD)fed with low-dose streptozotocin(STZ)treated(HFD/STZ)mice(β-cell dysfunction model)and db/db mice(genetic insulin resistance model).Methods The established HFD/STZ and db/db diabetic mice were respectively and Objective To explore the possible mechanism of rAd-p53 involved in glucose metabolism by observing the different effects of rAd-p53 on high-fat diet (HFD) fed with low-dose streptozotocin (STZ) treated (HFD / STZ) mice cell dysfunction model) and db / db mice (genetic insulin resistance model). Methods The established HFD / STZ and db / db diabetic mice were respectively and