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目的:观察培哚普利加丹红注射液治疗高血压病早期肾损害的临床效果及不良反应。方法:选择高血压病早期肾损害84例,随机分为观察组和对照组各42例。对照组采用口服培哚普利治疗,每天4mg;观察组在对照组治疗的基础上,增加丹红注射液,每次20ml,加入5%葡萄糖注射液或0.9%氯化钠注射液250ml中静脉滴注,每天1次。均治疗30天,比较两组治疗前后尿蛋白排泄率(UAER)、收缩压(SBP)、舒张压(DBP)、血肌酐(Scr)、血尿素氮(BUN)、总胆固醇(TC)、三酰甘油(TG)指标变化。结果:观察组与对照组治疗后UAER、TG、TC指标分别为(72.2±24.8)μg/min、(2.2±1.1)mmol/L、(5.2±0.4)mmol/L和(86.8±20.4)μg/min、(2.9±0.9)mmol/L、(6.2±0.3)mmol/L;两组比较,差异显著(P<0.05)。两组治疗后SBP、DBP、Scr、BUN比较,差异不显著(P>0.05)。观察组和对照组分别发生咳嗽2例和1例。结论:培哚普利加丹红注射液治疗高血压病早期肾损害的效果优于单纯培哚普利治疗。
Objective: To observe the clinical effects and adverse reactions of perindopril plus red injection in the treatment of early renal damage in hypertensive patients. Methods: Eighty-four cases of early renal damage in hypertensive patients were randomly divided into observation group and control group with 42 cases each. The control group was treated with oral perindopril, 4mg per day. The observation group was given Danhong injection 20ml each time. The observation group was treated with 5% glucose injection or 0.9% sodium chloride injection 250ml medium vein Drip, 1 day. After treatment for 30 days, the urinary protein excretion rate (UAER), SBP, DBP, Scr, BUN, TC, Acylglycerol (TG) indicators change. Results: The indexes of UAER, TG and TC in observation group and control group were (72.2 ± 24.8) μg / min, (2.2 ± 1.1) mmol / L, (5.2 ± 0.4) mmol / L and (86.8 ± 20.4) μg /min, (2.9 ± 0.9) mmol / L, (6.2 ± 0.3) mmol / L; The difference between the two groups was significant (P <0.05). There were no significant differences in SBP, DBP, Scr and BUN after treatment between the two groups (P> 0.05). Two cases of cough and one case of cough occurred in observation group and control group. Conclusion: The effect of perindopril plus red injection in the treatment of early renal damage in hypertensive patients is better than that of perindopril alone.