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β阻滞剂不仅用于心绞痛和心律失常,目前对高血压、肥厚型心肌病、二尖瓣脱垂、倔头痛、青光眼和甲亢均有应用β阻滞剂治疗的报告。如何选择β阻滞剂呢?作者认为,应根据不同药物的药代动力学及药理,并结合病人具体情况进行选择。哮喘和支气管痉挛性慢性支气管炎病人,应尽量避免应用各种β阻滞剂。但选择性β_1阻滞剂如醋丁酰心安(acebutolol)、氨酰心安(atenolol)和美多心安(metoprolol)可少量应用,有部分激动剂作用(partial agonist activity)的β阻滞荆,如心得静(pindolol)、心得平(oxprenolol)和同时具有α肾上
Beta blockers are not only used for angina pectoris and arrhythmia, but are currently reported on beta blockers for hypertension, hypertrophic cardiomyopathy, mitral valve prolapse, stubborn headache, glaucoma, and hyperthyroidism. How to choose beta blockers? The author believes that should be based on the pharmacokinetics of different drugs and pharmacology, combined with the specific circumstances of patients to choose. Asthmatic and bronchospastic chronic bronchitis patients should try to avoid the use of various β blockers. However, selective beta-blockers such as acebutolol, atenolol and metoprolol may be used in small doses with beta agonists with partial agonist activity, Pindolol, oxprenolol and alpha-adrenoceptor at the same time