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1871年Taffe氏首先在生物体中发现葡萄糖醛酸。1897年Schmiedeberg和Meyer氏分离成功。此后,Fisher和Polity二氏主张它是葡萄糖的氧化产物,是肝脏解毒的物質之一,因此逐渐引起注意。一、分布与形成: 其分布和形成机转至今尚不十分清楚。有些人认为,葡萄糖醛酸是正常代谢的分解产物;同时有些人坚持它是非正常情况的分解产物。然而,体内与蛋白質结合成所谓“醣蛋白”形式存在,是以组织中醣的形式存在,这些是逐渐被公认了。葡萄糖醛酸的结合体葡萄糖甙酸(GIucuronide)以磷酸软骨素的形式
1871 Taffe’s first discovery of glucuronic acid in living organisms. 1897 Schmiedeberg and Meyer’s success. Since then, Fisher and Polity two advocate it is the oxidation of glucose products, one of the liver detoxification substances, so gradually attracted attention. First, the distribution and formation: the distribution and formation of the machine is still not very clear. Some people think that glucuronic acid is a normal metabolic breakdown products; at the same time some people insist it is a breakdown of abnormal conditions. However, the combination of the body and the protein in the form of the so-called “glycoprotein” exists in the form of sugars in the tissues and these are gradually being recognized. Glucuronic acid conjugate Glucosidase (GIucuronide) in the form of phosphorylated chondroitin