B 型单胺氧化酶(MAOB)在 N-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森综合征的发病中起着关键作用,MPTP 选择性引起黑质纹状体多巴胺能神经元变性,并激活 MAOB。在脑内和人类血小板内,3-氢 MPTP 与 MAOB 之间有着一致的结合位点。鉴于对帕金森病(PD)患者与正常人之间的血小板 MAOB 活力的可能差异尚有疑问,作者观察了一组 PD 病人血小板的 MAOB。病人和方法选择18例特发性 PD,男11例,女 Type B monoamine oxidase (MAOB) plays a pivotal role in the pathogenesis of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced Parkinson’s disease and MPTP selectively induces black Striatum dopaminergic neurons degenerate and activate MAOB. There is a consistent binding site between 3-hydrogen MPTP and MAOB in the brain and in human platelets. Given the fact that there is a question of the possible differences in platelet MAOB viability between Parkinson’s disease (PD) patients and normal subjects, the authors looked at the MAOB of a panel of patients with PD. Patient and method 18 cases of idiopathic PD were selected, including 11 males and 11 females