论文部分内容阅读
目的:分析三维适形放射治疗食管癌的疗效和放射治疗反应。方法:选择96例初治食管癌患者,分为三维适形放疗(3DCRT)组43例和常规放疗(CF)组53例。CF组2.0 Gy/次,5次/周,总剂量50~68 Gy;3DCRT组先常规放疗20 Cy,方法同CF组,然后改用三维适形放疗,2.0 Gy/次,5次/周,总剂量50~70 Gy。结果:3DCRT组和CF组的总有效率(CR+PR)分别为93.0%、86.8%,差异有统计学意义(χ2=7.569,P<0.05)。3DCRT组和CF组的1、2、3年生存率分别为72.1%、48.8%、32.6%和56.6%、32.1%、20.8%,差异无统计学意义(χ2=3.409,P>0.05)。3DCRT组1、2、3年局控率分别为72.1%、60.5%、53.5%,CF组的分别为62.3%、41.5%、34%,差异有统计学意义(χ2=4.693,P<0.05)。2组患者的放射性食管炎发生率比较差异无统计学意义(χ2=2.859,P>0.05),白细胞减少发生率比较差异无统计学意义(χ2=2.199,P>0.05)。结论:3DCRT能提高食管癌的近期疗效和局控率,未提高中期生存率,放疗毒副反应可耐受,远期生存率有待进一步观察
Objective: To analyze the curative effect and radiation therapy response of three-dimensional conformal radiotherapy for esophageal cancer. Methods: Ninety-six patients with newly diagnosed esophageal cancer were selected and divided into three groups: 43 cases in 3DCRT group and 53 cases in conventional radiotherapy group. CF group 2.0 Gy / time, 5 times / week, the total dose of 50 ~ 68 Gy; 3DCRT group conventional radiotherapy 20 Cy, the same method of CF group, and then use three-dimensional conformal radiation therapy, The total dose of 50 ~ 70 Gy. Results: The total effective rate (CR + PR) of 3DCRT group and CF group was 93.0% and 86.8% respectively, with significant difference (χ2 = 7.569, P <0.05). The 1-, 2- and 3-year survival rates of 3DCRT group and CF group were 72.1%, 48.8%, 32.6% and 56.6%, 32.1% and 20.8%, respectively, with no significant difference (χ2 = 3.409, P> 0.05). In the 3DCRT group, the rates of local control were 72.1%, 60.5% and 53.5% at 1, 2, and 3 years respectively, and those in the CF group were 62.3%, 41.5% and 34% respectively (χ2 = 4.693, P <0.05) . There was no significant difference in the incidence of radiation esophagitis among the two groups (χ2 = 2.859, P> 0.05). The incidence of leukopenia was no significant difference (χ2 = 2.199, P> 0.05). Conclusion: 3DCRT can improve the short-term curative effect and control rate of esophageal cancer without increasing the medium-term survival rate. The toxic side effects of radiotherapy can be tolerated. The long-term survival rate needs to be further observed