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目的探讨门静脉灌注化疗预防大肠癌肝转移的临床价值。方法将132例大肠癌患者随机分为两组,治疗组(67例)术后早期进行门静脉灌注化疗,对照组(65例)单纯接受大肠癌根治术。观察两组术后肝转移发生率及5年生存率。结果治疗组术后肝转移发生率164%(11/67例),1、3、5年生存率分别为97%、806%、746%;对照组术后肝转移发生率446%(29/65),1、3、5年生存率分别为969%、615%、538%。结论大肠癌根治术后早期门静脉化疗能降低肝转移发生率并提高5年生存率。
Objective To investigate the clinical value of portal vein chemotherapy in preventing liver metastasis from colorectal cancer. Methods A total of 132 patients with colorectal cancer were randomly divided into two groups. The treatment group (67 cases) received portal vein infusion chemotherapy immediately after operation, while the control group (65 cases) received simple colon cancer radical operation. The incidence of postoperative liver metastases and 5-year survival rate were observed. Results The incidence of postoperative liver metastasis in the treatment group was 164% (11/67 cases), and the 1,3 and 5 year survival rates were 97%, 806% and 746% respectively. The incidence of postoperative liver metastasis in the control group was 446% (29 / 65). The 1, 3, 5 year survival rates were 969%, 615% and 538% respectively. Conclusions Early portal chemotherapy after radical operation of colorectal cancer can reduce the incidence of liver metastasis and increase the 5-year survival rate.