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主动脉瓣膜钙化可引起主动脉瓣狭窄、关闭不全等疾病,导致老年退行性瓣膜病的重要病理改变。西方国家整体人群中发病率达2.5%,严重危害患者生命安全,造成沉重的社会负担。由于除手术外缺乏有效的治疗手段,因此探讨主动脉瓣瓣膜钙化的机制,研究阻断其病理过程进展的可能性已经成为近年来心脏外科医师关注的热点之一[1]。原子力显微镜(AFM)以其能够以高分辨率和简单制样方法观察生物样品的表面精细结构的特征,
Aortic valve calcification can cause aortic stenosis, incomplete closure and other diseases, leading to degenerative valvular disease of the elderly important pathological changes. The incidence of the general population in Western countries up to 2.5%, seriously endangering patients’ lives and safety, causing heavy social burden. Due to the lack of effective treatment in addition to surgery, the discussion of the mechanism of aortic valve calcification and the possibility of blocking the progression of the pathological process have become one of the hot topics of cardiac surgeons in recent years [1]. Atomic Force Microscopy (AFM) With its ability to observe the characteristics of surface fine structures of biological samples in high resolution and simple sample preparation methods,