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目的了解辽宁省1~29岁人群乙型肝炎(乙肝)感染现状,评价乙肝疫苗免疫策略的效果。方法采用分层二阶段整群随机抽样方法抽取辽宁省6个县区1 756人为研究对象采集血清,用ELISA进行乙肝3项指标检测。结果辽宁省1~29岁人群HBs Ag阳性率为0.68%,标化阳性率为1.58%;Anti-HBs阳性1 035例,阳性率58.94%,标化阳性率为53.41%;Anti-HBc阳性者88例,阳性率为5.01%,标化阳性率为9.60%;男女性3项指标阳性率比较差异均无统计学意义;各年龄组调查人群比较,HBs Ag阳性率最高为20~24岁组(3.60%),Anti-HBs阳性率最高为1~4岁组(71.51%),Anti-HBc阳性率最高为25~29岁组(18.64%),HBs Ag和Anti-HBc阳性率呈现总体趋势随着年龄增大而升高;是否有疫苗免疫史的人群HBs Ag、Anti-HBs和Anti-HBc阳性率比较差异均有统计学意义。结论辽宁省HBs Ag阳性率下降,疫苗接种效果明显。
Objective To understand the status of hepatitis B (hepatitis B) infection in people aged from 1 to 29 in Liaoning Province and evaluate the effect of hepatitis B vaccine immunization strategy. Methods A stratified two-stage cluster random sampling method was used to collect 1 756 people from 6 counties of Liaoning Province for the study of serum samples, and 3 indexes of hepatitis B were detected by ELISA. Results The positive rate of HBsAg was 0.68% and the standardization rate was 1.58% in 1 ~ 29 years old population in Liaoning province. The positive rate of Anti-HBs was 1 035 cases, the positive rate was 58.94% and the positive rate was 53.41% 88 cases, the positive rate was 5.01%, the standardized positive rate was 9.60%; the positive rate of the three indicators of men and women were no significant difference; the age groups surveyed population, the highest positive rate of HBsAg 20 to 24 years old group (3.60%). The highest positive rate of Anti-HBs was in the group of 1 to 4 years old (71.51%) and the highest positive rate of Anti-HBc was in the group of 25-29 years old (18.64%). The positive rates of HBs Ag and Anti- With the increase of age, the positive rate of HBsAg, Anti-HBs and Anti-HBc in the population with or without vaccine immunization had statistical significance. Conclusion The positive rate of HBsAg in Liaoning Province decreased, and the vaccination effect was obvious.