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低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)是心血管病的危险因素,已经被流行病学和随机试验证实。鉴于LDL-C的重要性,国家心脏、肺和血液协会于30年前成立了国家胆固醇教育项目,教育内科医生和普通民众较低的血胆固醇可以减少严重血管事件的风险。尽管降低LDL-C的价值已经得到共识,但是随着时间的推移,推荐的方案也发生了变化。临床上他汀类药物降低LDL-C的益处已经被广泛接受,但是非他汀类药物降低LDL-C的益处
Low density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease and has been confirmed by epidemiological and randomized trials. Given the importance of LDL-C, the National Heart, Lung, and Blood Association established a national cholesterol education program 30 years ago to educate physicians and lower blood cholesterol levels in the general public to reduce the risk of serious vascular events. Although consensus has been reached on lowering the value of LDL-C, the recommended protocols have also changed over time. The benefits of statins lowering LDL-C have been widely accepted clinically, but the benefits of non-statin lowering LDL-C