临床上氨苄青霉素采用一日一次大剂量给药方案,使静点开始阶段血药水平过高,容易造成药热等不良反应,并由于半衰期很短,一天之中大部分血药浓度达不到治疗水平,进行实验研究,用微生物法测定了家兔血清中氨苄青霉素的浓度,以此结果提出了一天静滴两次或静滴和口服相结合的合理用药方案。 Clinically, ampicillin is administered in a large dose once a day so as to make the blood level of drug in the initial stage of static point too high, which is likely to cause adverse reactions such as drug fever and the like. Due to the short half-life and most of the plasma concentration in a day Treatment level, the experimental study, the determination of the concentration of ampicillin in rabbits serum by microbiological methods, the results of the proposed intravenous drip twice a day or a combination of intravenous and oral rational use of the program.