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趋化因子(chemokines)是指具有吸引白细胞移行到感染部位的一些低分子量、趋化因子大小为8~10 kD的蛋白质。CXCR4及CXCR2是趋化因子受体家族中的重要成员。其在肿瘤转移中的作用己经分别在乳腺癌、非小细胞肺癌、结直肠癌、胃癌等研究中得到证实[1]。国内及国外在此方面的研究报道较少[1-4]。趋化因子与趋化因子受体在肿瘤转移的多个阶段均发挥调控作用[2-4]。本研究于2011
Chemokines are proteins that have a low molecular weight and have chemokine sizes of 8-10 kD that allow leukocytes to migrate to the site of infection. CXCR4 and CXCR2 are important members of the chemokine receptor family. Its role in tumor metastasis has been confirmed in breast cancer, non-small cell lung cancer, colorectal cancer, gastric cancer and other studies have been confirmed [1]. Domestic and foreign research reports in this area less [1-4]. Chemokines and chemokine receptors play a regulatory role in multiple stages of tumor metastasis [2-4]. This study was conducted in 2011