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目的观察康复新液联合质子泵抑制剂及促动力药物治疗不同亚型非糜烂性反流病(NERD)的疗效。方法收集NERD患者123例,根据24h动态食管p H监测De Meester积分及症状指数分为异常酸反流型和对酸高敏型。两型患者均随机分为对照组(泮托拉唑肠溶胶囊每次40mg,每天2次;多潘立酮每次10mg,每天3次)、观察组(泮托拉唑肠溶胶囊每次40mg,每天2次;多潘立酮每次10mg,每天3次;康复新液每次10ml,每天3次),治疗2周,比较治疗前、治疗后1周、治疗后2周的症状积分及治疗后2周的疗效。结果治疗后,异常酸反流型对照组1与观察组1的症状积分明显减少,有效率分别达83.3%、90.3%;对酸高敏型观察组2症状积分减少较对照组2明显,有效率分别为86.1%、40.0%;对照组1与对照组2比较,症状积分与有效率差异均有统计学意义(P<0.05);观察组1与观察组2比较,症状积分与有效率差异均无统计学意义(P>0.05)。结论对于各型NERD患者的治疗,在抑酸及促动力的基础上加用促进黏膜修复的康复新液均可取得较理想的效果,是一种良好的临床联合用药方案。
Objective To observe the curative effect of Kangfuxin solution combined with proton pump inhibitor and motility drug in the treatment of different subtypes of non-erosive reflux disease (NERD). Methods A total of 123 patients with NERD were enrolled. According to 24h dynamic esophageal p H monitoring, De Meester score and symptom index were divided into abnormal acid reflux and hypersensitivity. Two types of patients were randomly divided into control group (pantoprazole enteric-coated capsules 40mg, 2 times a day; domperidone 10mg, 3 times a day), the observation group (pantoprazole enteric-coated capsules 40mg, 2 times; domperidone 10mg each time, 3 times a day; rehabilitation of the new liquid 10ml, 3 times a day) for 2 weeks, before treatment, 1 week after treatment, 2 weeks after treatment symptoms and 2 weeks after treatment Efficacy. Results After treatment, the symptom scores of abnormal acid reflux group 1 and observation group 1 were significantly reduced, the effective rates were 83.3% and 90.3% respectively; the reduction of symptom scores of 2 groups in hypersensitivity observation group was more obvious than that of control group 2 (86.1%, 40.0% respectively). The difference between symptom score and effective rate in control group 1 and control group 2 was statistically significant (P <0.05). The difference between symptom score and effective rate in observation group 1 and observation group 2 No statistical significance (P> 0.05). Conclusions For the treatment of various NERD patients, it is a good clinical combination regimen that the combination of acid and propofol can be used to improve the mucosal repair.