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有证据表明,Barrett上皮形成是慢性胃食管返流所致。24小时pH监测提示,Barrett食管患者食管的酸廓清能力降低,食管接触酸的时间延长。然而,在以减少胃酸分泌为基础治疗的同时,对患者胃酸分泌的潜在异常却未引起注意。为此,作者分析伴或不伴有Ba-rrett上皮的返流性食管炎患者的胃酸分泌功能,并与正常人作对比。同时,评价组胺受体和胆碱能阻滞剂对患者组胃酸分泌功能的影响。材料和方法:17例有慢性胃食管返流症状患者中10例经内镜活检诊断为Barrett食管,7例无Barrett上皮化生,全部患者均无胃十二指肠溃疡、胃食管手术、
There is evidence that Barrett epithelium is caused by chronic gastroesophageal reflux. A 24-hour pH monitoring suggests that esophageal acid clearance is reduced in patients with Barrett’s esophagus and esophageal acid exposure is prolonged. However, while treating gastric acid secretion as a basis, the potential abnormalities of gastric acid secretion in patients have not been noticed. To do this, the authors analyzed gastric acid secretion in patients with reflux esophagitis with and without Ba-rrett epithelium and compared them to normal subjects. At the same time, the effects of histamine receptors and cholinergic blockers on gastric acid secretion in patients were evaluated. MATERIALS AND METHODS: Ten patients with chronic gastroesophageal reflux syndrome were diagnosed as Barrett ’s esophagus by endoscopic biopsy and 7 without Barrett’ s epithelial metaplasia. None of the patients had gastroduodenal ulcer, gastroesophageal surgery,